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Kryptonite is a fictional substance which is the most well-known weakness of the DC Comics superhero Superman. Kryptonite is the ore form of a radioactive element (prior to Crisis on Infinite Earths) or compound (post-Crisis) from Superman's home planet of Krypton. The popularity of Superman and his vulnerability to Kryptonite has led to the generic usage of the term in popular culture as a reference to an individual's weakness, similar to "Achilles' heel".
First mentioned in The Adventures of Superman radio show in June 1943, Kryptonite has been featured in a variety of forms and colors (each with its own effect) in DC Comics publications and other media including: feature films, television series, and novelty items such as toys and trading card sets.
Superman and all other Kryptonian characters are susceptible to Kryptonite radiation. In the Modern Age of Comic Books, it is established that Kryptonite can also affect non-Kryptonians though at a much slower rate, causing humans to develop acute radiation syndrome or superhuman abilities. Wikipedia